A Tale of Two Binding Sites

A Tale of Two Binding Sites

The Ligand Binding Site

The Ligand Binding Site

The Co-Activator Binding Site

The Co-Activator Binding Site

A Tale of Two Binding Sites

Comparison of small molecule docking results of a compound into two potential binding sites on the protein. The modeling predicted the co-activator binding site as the probable location of drug binding (the site on the left in the marmoset structure) based on the greater number of favorable interactions. For more information, see https://www.ncbi.nlm.nih.gov/pubmed/29626009

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